BRAP Gene Summary [Human]
The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | BRAP |
| Official Name | BRCA1 associated protein [Source:HGNC Symbol;Acc:HGNC:1099] |
| Ensembl ID | ENSG00000089234 |
| Bio databases IDs | |
| Aliases | BRCA1 associated protein, impedes mitogenic signal propagation, galectin-2-binding protein |
| Synonyms | 3010002G07Rik, BRAP2, BRCA1 associated protein, IMP, RNF52 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BRAP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Coiled-coil region of CCDC155 or KASH
- RNA recognition motif (RRM) superfamily
- ubiquitin protein ligase activity
- Ubiquitin Carboxyl-terminal Hydrolase-like zinc finger
- coiled-coil domain
- enzyme
- Ring finger domain
- protein binding
- nuclear localization sequence binding
- identical protein binding
- BRCA1-associated protein 2
- ubiquitin ligase-like domain
- Zn-finger in ubiquitin-hydrolases and other protein
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- ubiquitin-protein transferase activity
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- alcoholism
- epilepsy
- myocardial infarction
- psoriasis
- alcohol use disorder
- flushing response
- non-insulin-dependent diabetes mellitus
role in cell
- proliferation
- growth
- cell death
- accumulation in
- nuclear import in
- palbociclib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- cytosol
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human BRAP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- MAPK cascade
- negative regulation of signal transduction
- Ras protein signal transduction
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- ubiquitin ligase complex
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleic acid binding
- ubiquitin-protein ligase activity
- zinc ion binding
- identical protein binding
- protein binding
- nuclear localization sequence binding