MUL1 Gene Summary [Human]
Enables several functions, including p53 binding activity; ubiquitin protein ligase binding activity; and ubiquitin-like protein transferase activity. Involved in several processes, including negative regulation of defense response; positive regulation of cellular protein metabolic process; and regulation of mitochondrion organization. Located in several cellular components, including mitochondrion; neuronal cell body; and peroxisome. Is integral component of mitochondrial outer membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | MUL1 |
| Official Name | mitochondrial E3 ubiquitin protein ligase 1 [Source:HGNC Symbol;Acc:HGNC:25762] |
| Ensembl ID | ENSG00000090432 |
| Bio databases IDs | |
| Aliases | mitochondrial E3 ubiquitin protein ligase 1, ring finger protein 218, mitochondria-anchored protein ligase, growth inhibition and death E3 ligase, mitochondrial ubiquitin ligase activator of NFKB 1 |
| Synonyms | 0610009K11Rik, C1orf166, GIDE, LOC100048020, MAPL, mitochondrial E3 ubiquitin protein ligase 1, mitochondrial ubiquitin ligase activator of NFKB 1, MULAN, RGD1309944, RNF218 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MUL1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- ubiquitin protein ligase binding
- SUMO transferase activity
- ubiquitin protein ligase activity
- enzyme
- Ring finger domain
- p53 binding
- protein binding
- identical protein binding
- E3 Ubiquitin ligase
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- mitochondrial outer membrane
- peroxisomes
- perikaryon
- axons
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MUL1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein sumoylation
- protein polyubiquitination
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- negative regulation of type I interferon-mediated signaling pathway
- positive regulation of mitochondrial fission
- negative regulation of innate immune response
- mitochondrial fission
- protein destabilization
- cellular response to exogenous dsRNA
- negative regulation of mitochondrial fusion
- regulation of mitochondrial membrane potential
- negative regulation of cell growth
- apoptotic process
- negative regulation of chemokine (C-C motif) ligand 5 production
- positive regulation of protein sumoylation
- regulation of mitochondrion organization
- activation of cysteine-type endopeptidase activity involved in apoptotic process
- protein stabilization
- mitochondrion localization
- negative regulation of defense response to virus by host
- negative regulation of protein kinase B signaling cascade
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- peroxisome
- mitochondrion
- membrane
- neuronal cell body
- mitochondrial outer membrane
- axon
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- identical protein binding
- p53 binding
- protein binding
- ubiquitin protein ligase binding
- metal ion binding
- SUMO ligase activity