ZNF268 Gene Summary [Human]
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of NIK/NF-kappaB signaling; positive regulation of nitrogen compound metabolic process; and regulation of apoptotic process. Located in actin cytoskeleton; cytosol; and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | ZNF268 |
| Official Name | zinc finger protein 268 [Source:HGNC Symbol;Acc:HGNC:13061] |
| Ensembl ID | ENSG00000090612 |
| Bio databases IDs | |
| Aliases | zinc finger protein 268 |
| Synonyms | HZF3, zinc finger protein 268 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ZNF268 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- krueppel associated box
- transcription regulator
- Zinc-finger double domain
- protein binding
- KRAB (Kruppel-associated box) domain -A box
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-insulin-dependent diabetes mellitus
- osteoarthritis
- coronary artery disease
- squamous cell cervical cancer
- cardiovascular disorder
role in cell
- apoptosis
- phosphorylation in
- activation in
- proliferation
- migration
- differentiation
- cell cycle progression
- colony formation
- response by
- degradation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ZNF268 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- positive regulation of cell proliferation
- regulation of transcription, DNA-dependent
- positive regulation of cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- regulation of mitotic cell cycle
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of apoptotic process
- positive regulation of apoptotic process
- cell differentiation
- regulation of cell cycle
- positive regulation of cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- cytosol
Molecular Function
What the gene product does at the molecular level
- DNA binding
- sequence-specific DNA binding transcription factor activity
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription