GOLGA3 Gene Summary [Human]
The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs). Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes a member of the golgin family of proteins which are localized to the Golgi. Its encoded protein has been postulated to play a role in nuclear transport and Golgi apparatus localization. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Feb 2010]
Details
| Type | Protein Coding |
| Official Symbol | GOLGA3 |
| Official Name | golgin A3 [Source:HGNC Symbol;Acc:HGNC:4426] |
| Ensembl ID | ENSG00000090615 |
| Bio databases IDs | |
| Aliases | golgin A3, SY2/SY10 protein, Golgi complex-associated protein of 170 kD |
| Synonyms | 5330413L04, 5430416E01Rik, G1-499-14, GCP170, golgin A3, MEA-2, Mea2/Golga3, repro27 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GOLGA3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitotic checkpoint protein
- Crescentin protein
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- Hyaluronan mediated motility receptor N-terminal
- Synaptonemal complex protein 1 (SCP-1)
- alpha helix
- Myosin tail
- helix-rich Mycoplasma protein
- coiled-coil domain
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- cleavage site
- head domain
- Alpha helical coiled-coil rod protein (HCR)
- chromosome segregation protein SMC, common bacterial type
- RecF/RecN/SMC N terminal domain
- RIM-binding protein of the cytomatrix active zone
- Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
- Coiled-coil domain-containing protein 158
- Intermediate filament protein
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- metabolic syndrome X
- central nervous system cancer
role in cell
- quantity
- formation in
- formation
- distribution
- translocation in
- breakdown
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- perinuclear region
- Golgi Apparatus
- cytoplasmic aggregates
- ER-to-Golgi intermediate compartment
- cytosol
- Golgi membrane
- Golgi stacks
- nucleoplasm
- nucleoli
- neurites
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GOLGA3 gene, providing context for its role in the cell.
Cellular Component
Where in the cell the gene product is active
- Golgi cisterna membrane
- membrane
- cytosol
- Golgi membrane
- Golgi apparatus
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding