CMTM6 Gene Summary [Human]
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and transmembrane 4 superfamilies. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 3. This gene is widely expressed in many tissues, but the exact function of the encoded protein is unknown. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CMTM6 |
| Official Name | CKLF like MARVEL transmembrane domain containing 6 [Source:HGNC Symbol;Acc:HGNC:19177] |
| Ensembl ID | ENSG00000091317 |
| Bio databases IDs | |
| Aliases | CKLF like MARVEL transmembrane domain containing 6 |
| Synonyms | 2810051A14Rik, CKLF-like MARVEL transmembrane domain containing 6, CKLFSF6, Da2-17, LRRGT00102, PRO2219 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CMTM6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- cytokine
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- pancreatic epithelial cancer
- endocervical adenocarcinoma
- endocervical cancer
- epithelial uterine cancer
- pancreatic adenocarcinoma
- cervical cancer
regulated by
- MIRN133A
- dexamethasone
- megakaryocytes
- PPIF
role in cell
- expression in
- proliferation
- quantity
- migration
- differentiation
- invasion by
- degradation in
- proliferative capability
- invasiveness
- migratory capacity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
- Plasma Membrane
- secretory granule membrane
- specific granule membrane
- lysosome membrane
- endosomal membrane
- recycling endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CMTM6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein stability
- protein transport
- endocytic recycling
Cellular Component
Where in the cell the gene product is active
- early endosome membrane
- membrane
- recycling endosome membrane
- azurophil granule membrane
- plasma membrane
- specific granule membrane
Molecular Function
What the gene product does at the molecular level
- protein binding