TEKT2 Gene Summary [Human]

This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is expressed in the testis and its protein is localized to the flagella of the sperms, indicating that it may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
TEKT2
Official Name
tektin 2 [Source:HGNC Symbol;Acc:HGNC:11725]
Ensembl ID
ENSG00000092850
Bio databases IDs NCBI: 27285 Ensembl: ENSG00000092850
Aliases tektin 2
Synonyms h-tektin-t, TEKTB1, tektin 2, TEKTIN-T
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TEKT2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • Tektin family

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • diabetic nephropathy
  • nonobstructive azoospermia
regulated by
  • lipopolysaccharide
  • ULK4
regulates
  • NPHS1
  • Axonemal Dynein Inner Arm
role in cell
  • expression in
  • motility
  • remodeling in
  • remodeling

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Cytoplasm
  • flagella
  • axonemes
  • microtubule organizing centers
  • sperm tail

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human TEKT2 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • sperm motility
  • cilium morphogenesis
  • cilium movement involved in cell motility
  • inner dynein arm assembly

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • axonemal microtubule
  • microtubule cytoskeleton
  • motile cilium
  • microtubule organizing center

Gene-Specific Assays for Results You Can Trust

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