POLDIP3 Gene Summary [Human]
This gene encodes an RRM (RNA recognition motif)-containing protein that participates in the regulation of translation by recruiting ribosomal protein S6 kinase beta-1 to mRNAs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | POLDIP3 |
| Official Name | DNA polymerase delta interacting protein 3 [Source:HGNC Symbol;Acc:HGNC:23782] |
| Ensembl ID | ENSG00000100227 |
| Bio databases IDs | |
| Aliases | DNA polymerase delta interacting protein 3, S6K1 Aly/REF-like target |
| Synonyms | 1110008P04Rik, DNA polymerase delta interacting protein 3, DNA polymerase δ interacting protein 3, mKIAA1649, PDIP3, PDIP46, polymerase (DNA-directed), delta interacting protein 3, polymerase (DNA-directed), δ interacting protein 3, SKAR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLDIP3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- binding protein
- RNA recognition motif
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytoplasmic ribonucleoprotein granule
- Cytoplasm
- cytosol
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLDIP3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of translation
- poly(A)+ mRNA export from nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- nuclear speck
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- mRNA binding