KAT2B Gene Summary [Human]
CBP and p300 are large nuclear proteins that bind to many sequence-specific factors involved in cell growth and/or differentiation, including c-jun and the adenoviral oncoprotein E1A. The protein encoded by this gene associates with p300/CBP. It has in vitro and in vivo binding activity with CBP and p300, and competes with E1A for binding sites in p300/CBP. It has histone acetyl transferase activity with core histones and nucleosome core particles, indicating that this protein plays a direct role in transcriptional regulation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | KAT2B |
| Official Name | lysine acetyltransferase 2B [Source:HGNC Symbol;Acc:HGNC:8638] |
| Ensembl ID | ENSG00000114166 |
| Bio databases IDs | |
| Aliases | lysine acetyltransferase 2B |
| Synonyms | A930006P13RIK, AABR07066180.1, AI461839, AW536563, CAF, K(lysine) acetyltransferase 2B, lysine acetyltransferase 2B, PCAF, P/CAF, Pcaf-b |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human KAT2B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone acetyltransferase domain
- Acetyltransferase (GNAT) family
- transcription regulator
- transcription co-activator
- Ada2 homology domain
- transcription cofactor
- transcription factor binding
- chromatin binding
- enzyme
- Bromodomain
- enzyme activator activity
- acetyltransferase domain
- acetyl CoA binding domain
- Acetyltransferase (GNAT) domain
- histone acetyltransferase binding
- histone acetyltransferase
- protein kinase binding
- catalytic domain
- nucleic acid binding
- NAT_SF
- histone deacetylase binding
- protein binding
- sequence-specific DNA binding
- cyclin-dependent protein kinase inhibitor activity
- N-acetyltransferase
- lysine N-acetyltransferase
- double-stranded DNA binding
- polyglutamine repeat
- PCAF (P300/CBP-associated factor) N-terminal domain
- acetyltransferase
- CBP binding domain
Pathways
Biological processes and signaling networks where the KAT2B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- neoplasia
- systemic lupus erythematosus
- male pattern hair loss
- ovarian cancer
- post-traumatic stress disorder
- growth failure
- advanced ovarian cancer
- heart failure
- kidney carcinoma
role in cell
- activation in
- apoptosis
- proliferation
- expression in
- ubiquitination in
- differentiation
- transcription in
- binding in
- transactivation in
- induction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- actin cytoskeleton
- centrosome
- sarcomere
- cytosol
- nucleoplasm
- nuclear speckles
- I band
- kinetochores
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human KAT2B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of cell proliferation
- regulation of DNA repair
- vasodilation
- positive regulation of transcription from RNA polymerase II promoter
- memory
- positive regulation of glycolysis
- positive regulation of transcription from RNA polymerase II promoter by glucose
- positive regulation of gluconeogenesis
- positive regulation of fatty acid biosynthetic process
- cellular response to insulin stimulus
- negative regulation of transcription from RNA polymerase II promoter
- regulation of cell division
- heart development
- chromatin remodeling
- peptidyl-lysine acetylation
- regulation of protein ADP-ribosylation
- positive regulation of transcription, DNA-dependent
- internal peptidyl-lysine acetylation
- cellular response to parathyroid hormone stimulus
- N-terminal peptidyl-lysine acetylation
- negative regulation of rRNA processing
- positive regulation of neuron projection development
- regulation of cell cycle
- gluconeogenesis
- positive regulation of gene expression, epigenetic
- limb development
- regulation of embryonic development
- regulation of tubulin deacetylation
- negative regulation of centriole replication
- regulation of transcription, DNA-dependent
- protein acetylation
- regulation of transcription from RNA polymerase II promoter
- rhythmic process
- regulation of RNA splicing
- cellular response to oxidative stress
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- mitotic spindle
- cytosol
- I band
- macromolecular complex
- A band
- kinetochore
- actomyosin
- SAGA complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- H3 histone acetyltransferase activity
- histone acetyltransferase binding
- acetyltransferase activity
- histone deacetylase binding
- RNA polymerase II regulatory region sequence-specific DNA binding
- histone acetyltransferase activity (H3-K9 specific)
- chromatin binding
- cyclin-dependent protein kinase inhibitor activity
- diamine N-acetyltransferase activity
- histone acetyltransferase activity
- lysine N-acetyltransferase activity
- protein binding
- transcription cofactor activity
- transcription coactivator activity