MAPK12
MAPK12 Gene Summary
Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | MAPK12 |
| Official Name | mitogen-activated protein kinase 12 [Source:HGNC Symbol;Acc:HGNC:6874] |
| Ensembl ID | ENSG00000188130 |
| Bio databases IDs | |
| Aliases | mitogen-activated protein kinase 12 |
| Synonyms | ERK3,ERK-6,LOC100509672,mitogen-activated protein kinase 12,P38GAMMA,P38 MAPK gamma,P38 MAP KINASE gamma,P38 MAP KINASE γ,P38 MAPK γ,P38 γ,PRKM12,SAPK-3 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Serine/Threonine protein kinases, catalytic domain
- protein serine/threonine kinase
- Protein Kinases, catalytic domain
- MAP kinase
- ATP binding
- threonine-glycine-tyrosine activation motif
- protein binding
- Protein kinase domain
- magnesium ion binding
- PDZ binding motif
- phosphorylation site
Pathways
Biological processes and signaling networks where the MAPK12 gene plays a role, providing insight into its function and relevance in health or disease.
- Amyloid Processing
- Apelin Liver Signaling Pathway
- Apelin Pancreas Signaling Pathway
- April Mediated Signaling
- B Cell Activating Factor Signaling
- Corticotropin Releasing Hormone Signaling
- CXCR4 Signaling
- GADD45 Signaling
- Glucocorticoid Receptor Signaling
- HGF Signaling
- IL-17A Signaling in Airway Cells
- IL-17A Signaling in Gastric Cells
- Induction of Apoptosis by HIV1
- Inhibition of Angiogenesis by TSP1
- LPS-stimulated MAPK Signaling
- MIF Regulation of Innate Immunity
- Mouse Embryonic Stem Cell Pluripotency
- Parkinson's Signaling
- PCP pathway
- PEDF Signaling
- Role of JAK family kinases in IL-6-type Cytokine Signaling
- Role of MAPK Signaling in the Pathogenesis of Influenza
- TGF-β Signaling
- Toll-like Receptor Signaling
- UVA-Induced MAPK Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- STUB1
- MAPK1
- TAB1
- ERBIN
- RPA2
- PRP4K
- GJC1
- MYLK3
- PTPN3
- SIAH1
disease
- cancer
- epithelial neoplasia
- epithelial cancer
- liver neoplasia
- liver cancer
- digestive system cancer
- abdominal cancer
- neoplastic cell transformation
- colon cancer
- hepatocellular carcinoma
regulated by
- anisomycin
- epigallocatechin-gallate
- tetradecanoylphorbol acetate
- TNF
- 1,25-dihydroxyvitamin D
- MAP2K3
- DDX3X
- insulin
- PAK2
- SB203580
regulates
- IL17A
- TP53
- TNF
- MMP9
- IL12 (complex)
- IL1B
- CASP3
- FOS
- EGFR
- ERK1/2
role in cell
- expression in
- growth
- phosphorylation in
- activation in
- apoptosis
- proliferation
- survival
- quantity
- production in
- differentiation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- neuromuscular junctions
- sarcolemma
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the MAPK12 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- muscle organ development
- MAPK cascade
- signal transduction
- signal transduction in response to DNA damage
- myoblast differentiation
- positive regulation of peptidase activity
- negative regulation of cell cycle
- regulation of cell cycle
- peptidyl-serine phosphorylation
- intracellular signal transduction
- positive regulation of muscle cell differentiation
CELLULAR COMPONENT
Where in the cell the gene product is active
- nucleus
- cytoplasm
- mitochondrion
- cytosol
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- magnesium ion binding
- ATP binding
- protein binding
- MAP kinase activity
- protein serine/threonine kinase activity