HDGF Gene Summary [Human]
This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2016]
Details
| Type | Protein Coding |
| Official Symbol | HDGF |
| Official Name | heparin binding growth factor [Source:HGNC Symbol;Acc:HGNC:4856] |
| Ensembl ID | ENSG00000143321 |
| Bio databases IDs | |
| Aliases | heparin binding growth factor, high-mobility group protein 1-like |
| Synonyms | D3Ertd299e, heparin binding growth factor, HMG1L2, Transformation-related |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HDGF often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleic acid binding
- transcription co-repressor
- nuclear localization sequence
- PWWP domain
- transcription factor binding
- PWWP (Pro-Trp-Trp-Pro) domain
- protein binding
- sequence-specific DNA binding
- growth factor
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional repressor activity
- tubulin binding
- double-stranded DNA binding
- actin binding
- heparin binding
- hath domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric cancer
- preeclampsia
- hepatic fibrosis
- Huntington disease
- overall survival
- motor dysfunction
role in cell
- production in
- quantity
- expression in
- proliferation
- apoptosis
- survival
- cell death
- migration
- invasive capability
- invasion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cell surface
- Nucleus
- nucleoplasm
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HDGF gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- signal transduction
- positive regulation of transcription from RNA polymerase II promoter
- protein localization to nucleus
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- cytoplasm
- transcriptional repressor complex
- extracellular region
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- transcription corepressor binding
- growth factor activity
- RNA binding
- transcription corepressor activity
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- heparin binding
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription