BCL7C Gene Summary [Human]

This gene is identified by the similarity of its product to the N-terminal region of BCL7A protein. The BCL7A protein is encoded by the gene known to be directly involved in a three-way gene translocation in a Burkitt lymphoma cell line. The function of this gene has not yet been determined. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Details

Type
Protein Coding
Official Symbol
BCL7C
Official Name
BAF chromatin remodeling complex subunit BCL7C [Source:HGNC Symbol;Acc:HGNC:1006]
Ensembl ID
ENSG00000099385
Bio databases IDs NCBI: 9274 Ensembl: ENSG00000099385
Aliases BAF chromatin remodeling complex subunit BCL7C
Synonyms BAF chromatin remodeling complex subunit BCL7C, B cell CLL/lymphoma 7C, C230096E12Rik, SMARCJ3
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human BCL7C often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • BCL7, N-terminal conserver region
  • protein binding
  • HTH domain in Mos1 transposase

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • diffuse cutaneous systemic sclerosis
regulated by

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human BCL7C gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • chromatin remodeling
  • regulation of mitotic metaphase/anaphase transition
  • negative regulation of cell differentiation
  • apoptotic process
  • positive regulation of cell proliferation
  • regulation of G1/S transition of mitotic cell cycle
  • positive regulation of double-strand break repair
  • regulation of nucleotide-excision repair
  • regulation of G0 to G1 transition
  • regulation of transcription from RNA polymerase II promoter

Cellular Component

Where in the cell the gene product is active
  • SWI/SNF complex
  • chromatin

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.