PHF10 Gene Summary [Human]

This gene contains a predicted ORF that encodes a protein with two zinc finger domains. The function of the encoded protein is not known. Sequence analysis suggests that multiple alternatively spliced transcript variants are derived from this gene but the full-length nature of only two of them is known. These two splice variants encode different isoforms. A pseudogene for this gene is located on Xq28. [provided by RefSeq, Jul 2008]

Details

Type
Protein Coding
Official Symbol
PHF10
Official Name
PHD finger protein 10 [Source:HGNC Symbol;Acc:HGNC:18250]
Ensembl ID
ENSG00000130024
Bio databases IDs NCBI: 55274 Ensembl: ENSG00000130024
Aliases PHD finger protein 10
Synonyms 1810055P05RIK, BAF45A, LOC106740, PHD finger protein 10, SMARCG4, XAP135
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PHF10 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • PHD zinc finger
  • WH_NTD_SMARCB1_like
  • PHD finger superfamily
  • protein binding

Pathways

Biological processes and signaling networks where the PHF10 gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • nonalcoholic steatohepatitis
regulated by
role in cell
  • expression in
  • accumulation
  • senescence

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • Cytoplasm
  • nucleoplasm

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human PHF10 gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • chromatin remodeling
  • regulation of mitotic metaphase/anaphase transition
  • positive regulation of T cell differentiation
  • nervous system development
  • positive regulation of myoblast differentiation
  • positive regulation of cell differentiation
  • regulation of G1/S transition of mitotic cell cycle
  • regulation of nucleotide-excision repair
  • positive regulation of double-strand break repair
  • regulation of G0 to G1 transition
  • regulation of transcription from RNA polymerase II promoter

Cellular Component

Where in the cell the gene product is active
  • nucleus
  • SWI/SNF complex
  • npBAF complex
  • nuclear matrix
  • kinetochore
  • RSC complex
  • chromatin
  • nucleoplasm

Molecular Function

What the gene product does at the molecular level
  • histone acetyltransferase activity
  • transcription cofactor activity
  • metal ion binding
  • chromatin binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.