EIF3L
EIF3L Gene Summary
Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in translational initiation and viral translational termination-reinitiation. Located in membrane. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | EIF3L |
| Official Name | eukaryotic translation initiation factor 3 subunit L [Source:HGNC Symbol;Acc:HGNC:18138] |
| Ensembl ID | ENSG00000100129 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 3 subunit L |
| Synonyms | 0610011H21Rik,D15N1e,EIF3EIP,Eif3ip,EIF3S11,EIF3S6IP,eukaryotic translation initiation factor 3 subunit L,eukaryotic translation initiation factor 3, subunit L,HSP-66Y,HSPC021,HSPC025,MSTP005,PAF67 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA polymerase I-associated factor PAF67
- translation initiation factor
- protein binding
- translation regulator
Pathways
Biological processes and signaling networks where the EIF3L gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- ESR1
- ESR2
- BIRC3
- YWHAZ
- NR2C2
- PSMD14
- CCNF
- MYC
- SRP72
- RRN3
disease
- systemic autoimmune syndrome
- open-angle glaucoma
regulated by
- IL17A
- SOD1
- RYR1
- EIF3E
regulates
- RNA-directed RNA polymerase
role in cell
- cell death
- capivasertib resistance
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- fibrillar center
- cytosol
- nucleoplasm
- nucleoli
- synapse
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the EIF3L gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- formation of translation initiation complex
- translational initiation
CELLULAR COMPONENT
Where in the cell the gene product is active
- eukaryotic 43S preinitiation complex
- membrane
- cytosol
- synapse
- eukaryotic 48S preinitiation complex
- fibrillar center
- eukaryotic translation initiation factor 3 complex
- nucleoplasm
MOLECULAR FUNCTION
What the gene product does at the molecular level
- translation initiation factor activity
- RNA binding
- protein binding