POLR2F Gene Summary [Human]
This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. In yeast, this polymerase subunit, in combination with at least two other subunits, forms a structure that stabilizes the transcribing polymerase on the DNA template. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Details
| Type | Processed Transcript |
| Official Symbol | POLR2F |
| Official Name | RNA polymerase II, I and III subunit F [Source:HGNC Symbol;Acc:HGNC:9193] |
| Ensembl ID | ENSG00000100142 |
| Bio databases IDs | |
| Aliases | RNA polymerase II, I and III subunit F, DNA directed RNA polymerase II 14.4 kda polypeptide |
| Synonyms | 1810060D16RIK, HRBP14.4, LOC100131530, LOC105373026, LOC83503, POLRF, polymerase (RNA) II (DNA directed) polypeptide F, RNA polymerase II, I and III subunit F, RPABC14.4, RPABC2, RPB14.4, RPB6, RPC15 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human POLR2F often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- DNA-directed RNA polymerase
- enzyme
Pathways
Biological processes and signaling networks where the POLR2F gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Waardenburg-Shah syndrome neurologic variant
- Waardenburg syndrome type 4C
- androgenic alopecia
- hereditary disorder
- Waardenburg syndrome type 1
- Waardenburg syndrome type IIE with neurologic involvement
- Waardenburg syndrome type IIE
- Hirschsprung disease 1
- Waardenburg syndrome type 2A
- Hirschsprung disease
regulates
- DNA endogenous promoter
- FAS
- DNA promoter
- RNA polymerase iii
- RNA polymerase II
- RNA polymerase I
role in cell
- growth
- alternative splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- fibrillar center
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human POLR2F gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase I promoter
- transcription from RNA polymerase II promoter
- tRNA transcription from RNA polymerase III promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- DNA-directed RNA polymerase I complex
- cytosol
- DNA-directed RNA polymerase III complex
- fibrillar center
- nucleoplasm
- DNA-directed RNA polymerase II, core complex
Molecular Function
What the gene product does at the molecular level
- DNA binding
- RNA polymerase III activity
- RNA polymerase II activity
- RNA polymerase I activity