NELFCD Gene Summary [Human]
The NELF complex of proteins interacts with the DSIF protein complex to repress transcriptional elongation by RNA polymerase II. The protein encoded by this gene is an essential part of the NELF complex. Alternative translation initiation site usage results in the formation of two isoforms with different N-termini. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | NELFCD |
| Official Name | negative elongation factor complex member C/D [Source:HGNC Symbol;Acc:HGNC:15934] |
| Ensembl ID | ENSG00000101158 |
| Bio databases IDs | |
| Aliases | negative elongation factor complex member C/D, trihydrophobin 1 |
| Synonyms | 2410003I03Rik, HSPC130, negative elongation factor complex member C/D, negative elongation factor complex member C/D, Th1l, NELF-C, NELF-C/D, NELF-D, TH1, TH1L |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NELFCD often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- TH1 protein
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NELFCD gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- NELF complex
- membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding