Polr3h Gene Summary [Mouse]
Predicted to enable DNA-directed RNA polymerase activity. Predicted to be involved in transcription initiation at RNA polymerase III promoter. Predicted to be located in centrosome and nucleoplasm. Predicted to be part of RNA polymerase III complex. Is expressed in several structures, including alimentary system; limb; nervous system; respiratory system; and sensory organ. Used to study primary ovarian insufficiency. Orthologous to human POLR3H (RNA polymerase III subunit H). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Polr3h |
| Official Name | polymerase (RNA) III (DNA directed) polypeptide H [Source:MGI Symbol;Acc:MGI:1926179] |
| Ensembl ID | ENSMUSG00000022476 |
| Bio databases IDs | |
| Aliases | polymerase (RNA) III (DNA directed) polypeptide H |
| Synonyms | 5031409G22Rik, C25, MGC29654, polymerase (RNA) III (DNA directed) polypeptide H, RNA polymerase III subunit H, RPC22.9, RPC8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Polr3h often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- S1_like
- DNA-directed RNA polymerase (rpoE), archaeal and eukaryotic form
- DNA-directed RNA polymerase
- enzyme
- protein binding
- RNAP_Rpb7_N_like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hereditary disorder
- optic atrophy type 9
- infantile cerebellar-retinal degeneration
- autosomal recessive optic atrophy
- optic atrophy
regulates
- DNA promoter
- DNA endogenous promoter
- RNA polymerase iii
- nucleic acid component or derivative
role in cell
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- centrosome
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Polr3h gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase III promoter
- transcription initiation from RNA polymerase III promoter
- innate immune response
- defense response to virus
- nucleobase-containing compound metabolic process
Cellular Component
Where in the cell the gene product is active
- centrosome
- intracellular membrane-bounded organelle
- cytosol
- DNA-directed RNA polymerase III complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- DNA-directed RNA polymerase activity