DPP9 Gene Summary [Human]
This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | DPP9 |
| Official Name | dipeptidyl peptidase 9 [Source:HGNC Symbol;Acc:HGNC:18648] |
| Ensembl ID | ENSG00000142002 |
| Bio databases IDs | |
| Aliases | dipeptidyl peptidase 9 |
| Synonyms | 6430584G11RIK, A330078I11, dipeptidyl peptidase 9, DP9, DPLP9, DPP IX, DPRP-2, HATIS, IMD111 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DPP9 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Prolyl oligopeptidase family
- Dipeptidyl peptidase IV (DPP IV) N-terminal region
- alpha/beta hydrolase fold domain
- peptidase
- dipeptidyl-peptidase
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- interstitial lung disease
- idiopathic pulmonary fibrosis
- COVID-19
- renal clear cell adenocarcinoma
- renal clear cell cancer
- Hatipoglu immunodeficiency syndrome
- organismal death
- viral respiratory infection
- critical COVID-19
- severe COVID-19
role in cell
- expression in
- proliferation
- cell death
- apoptosis
- activation in
- accumulation in
- survival
- binding in
- inhibition in
- autophagy in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microtubules
- cytosol
- cell membrane leading edge
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DPP9 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteolysis
- pyroptosis
- negative regulation of programmed cell death
Cellular Component
Where in the cell the gene product is active
- nucleus
- cell leading edge
- cytosol
- microtubule
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- serine-type peptidase activity
- aminopeptidase activity
- dipeptidyl-peptidase activity