URI1 Gene Summary [Human]
This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22. [provided by RefSeq, Nov 2011]
Details
| Type | Protein Coding |
| Official Symbol | URI1 |
| Official Name | URI1 prefoldin like chaperone [Source:HGNC Symbol;Acc:HGNC:13236] |
| Ensembl ID | ENSG00000105176 |
| Bio databases IDs | |
| Aliases | URI1 prefoldin like chaperone, unconventional prefoldin RPB5 interactor, RPB5-mediating protein, protein phosphatase 1, regulatory subunit 19 |
| Synonyms | C19orf2, NNX3, PPP1R19, RGD1310358, RMP, URI, URI1 prefoldin like chaperone, URI1, prefoldin-like chaperone |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human URI1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- polr2e binding domain
- prefoldin
- transcription co-repressor
- enzyme binding
- phosphoprotein binding
- chromatin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- ovarian cancer
- serous ovarian adenocarcinoma
- serous ovarian cancer
- chronic periodontal disease
regulated by
- TCF4
- metribolone
role in cell
- proliferation
- growth
- expression in
- cell cycle progression
- apoptosis
- colony formation by
- transcription in
- recruitment in
- transactivation in
- invasiveness
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human URI1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular response to steroid hormone stimulus
- negative regulation of transcription from RNA polymerase II promoter
- negative regulation of phosphatase activity
- regulation of cell growth
- cellular response to growth factor stimulus
- response to virus
- protein stabilization
- negative regulation of intrinsic apoptotic signaling pathway
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- dendrite
- nucleus
- cytoplasm
- mitochondrion
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein phosphatase inhibitor activity
- protein binding
- transcription corepressor activity
- phosphatase inhibitor activity
- phosphoprotein binding
- chromatin binding
- RNA polymerase II core binding