SERPINA4 Gene Summary [Human]
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Located in extracellular exosome. Biomarker of diabetic retinopathy. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SERPINA4 |
| Official Name | serpin family A member 4 [Source:HGNC Symbol;Acc:HGNC:8948] |
| Ensembl ID | ENSG00000100665 |
| Bio databases IDs | |
| Aliases | serpin family A member 4, kallistatin |
| Synonyms | KAL, kallistatin, KLST, KST, PI-4, serpin family A member 4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SERPINA4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SERine Proteinase INhibitors (serpin) family
- serine protease inhibitor activity
- protein binding
- Serpin (serine protease inhibitor)
Pathways
Biological processes and signaling networks where the SERPINA4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- liver cancer
- cardiac injury
- diabetic nephropathy
- aortic valve calcification
- acute coronary syndrome
- hepatitis B virus-related hepatocellular carcinoma
regulated by
- heparin
- WNT3A
role in cell
- expression in
- activation in
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- cell surface
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SERPINA4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of endopeptidase activity
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- platelet dense granule lumen
- extracellular region
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity