PROCR Gene Summary [Human]
The protein encoded by this gene is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. The encoded protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | PROCR |
| Official Name | protein C receptor [Source:HGNC Symbol;Acc:HGNC:9452] |
| Ensembl ID | ENSG00000101000 |
| Bio databases IDs | |
| Aliases | protein C receptor |
| Synonyms | CCCA, CCD41, ENDOTHELIAL protein C receptor, EPCR, protein C receptor, protein C receptor, endothelial |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PROCR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MHC-I family domain
- extracellular domain
- signaling receptor activity
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- thrombocytopenia
- cancer
- neoplasia
- ischemic stroke
- myocardial infarction
- venous thromboembolism
- edema
- androgenic alopecia
- Crohn disease
- growth failure
role in cell
- expression in
- quantity
- production in
- upregulation in
- activation in
- phosphorylation in
- proliferation
- activation
- transactivation in
- molecular cleavage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- Cytoplasm
- cell surface
- Extracellular Space
- perinuclear region
- cellular membrane
- centrosome
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PROCR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of coagulation
- blood coagulation
Cellular Component
Where in the cell the gene product is active
- extracellular space
- centrosome
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- focal adhesion
- extracellular region
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity