TPT1 Gene Summary [Human]
This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Details
| Type | Protein Coding |
| Official Symbol | TPT1 |
| Official Name | tumor protein, translationally-controlled 1 [Source:HGNC Symbol;Acc:HGNC:12022] |
| Ensembl ID | ENSG00000133112 |
| Bio databases IDs | |
| Aliases | tumor protein, translationally-controlled 1 |
| Synonyms | FORTILIN, HRF, p02, p21, p23, TCTP, Tctp21, Trt, Tumor Protein Translationally-controlled 1, tumor protein, translationally-controlled 1, tumour Protein Translationally-controlled 1, tumour protein, translationally-controlled 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TPT1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Translationally controlled tumour protein
- calcium ion binding
- TCTP homology region
- transcription factor binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- Alzheimer disease
- COVID-19
- acute graft-vs-host disease
- Parkinson disease
- non-small cell lung carcinoma
- non-small cell lung cancer
- hyperglycemia
- susceptibility to acute infection-induced (herpes-specific) encephalopathy 10
role in cell
- expression in
- migration
- apoptosis
- formation
- formation in
- proliferation
- growth
- cell death
- quantity
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- cell periphery
- perinuclear region
- Nucleus
- Plasma Membrane
- Mitochondria
- cytosol
- nucleoplasm
- nucleoli
- spindle pole
- multivesicular bodies
- cytoplasmic microtubule
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TPT1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of apoptotic process
- calcium ion transport
- regulation of apoptotic process
- response to virus
- cellular calcium ion homeostasis
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular space
- extracellular vesicular exosome
- cytoplasm
- spindle pole
- cytosol
- cytoplasmic microtubule
- multivesicular body
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- calcium ion binding