PTOV1 Gene Summary [Human]
This gene encodes a protein that was found to be overexpressed in prostate adenocarcinomas. The encoded protein was found to interact with the lipid raft protein flotillin-1 and shuttle it from the cytoplasm to the nucleus in a cell cycle dependent manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Details
| Type | Protein Coding |
| Official Symbol | PTOV1 |
| Official Name | PTOV1 extended AT-hook containing adaptor protein [Source:HGNC Symbol;Acc:HGNC:9632] |
| Ensembl ID | ENSG00000104960 |
| Bio databases IDs | |
| Aliases | PTOV1 extended AT-hook containing adaptor protein |
| Synonyms | 1110030G05Rik, ACID2, GCAP3, prostate tumor over expressed gene 1, prostate tumour over expressed gene 1, PTOV1 extended AT-hook containing adaptor protein, PTOV1, extended AT-hook containing adaptor protein |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PTOV1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mediator complex subunit 25 PTOV activation and synapsin 2
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PTOV1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- perinuclear region of cytoplasm
- plasma membrane
- nucleoplasm