ADRB3 Gene Summary [Human]
The protein encoded by this gene belongs to the family of beta adrenergic receptors, which mediate catecholamine-induced activation of adenylate cyclase through the action of G proteins. This receptor is located mainly in the adipose tissue and is involved in the regulation of lipolysis and thermogenesis. Obesity and bodyweight-related disorders are correlated with certain polymorphisms in three subtypes of beta-adrenoceptor, among them, the ADRB3 gene.[provided by RefSeq, Oct 2019]
Details
| Type | Protein Coding |
| Official Symbol | ADRB3 |
| Official Name | adrenoceptor beta 3 [Source:HGNC Symbol;Acc:HGNC:288] |
| Ensembl ID | ENSG00000188778 |
| Bio databases IDs | |
| Aliases | adrenoceptor beta 3 |
| Synonyms | Adrab3, ADRB, adrenergic receptor, beta 3, adrenergic receptor, β 3, adrenoceptor beta 3, adrenoceptor β 3, beta-3 adrenergic receptor, Beta3 adrenoceptor, BETA3AR, β-3 adrenergic receptor, β 3-AR, β(3)AR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ADRB3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- hormone binding
- binding protein
- G-protein-coupled receptor binding
- intracellular domain
- protein homodimerization
- 7 transmembrane receptor (rhodopsin family)
- protein binding
- PXXP motif
- beta3-adrenergic receptor
- seven-transmembrane G protein-coupled receptor superfamily
- beta-adrenergic receptor
Pathways
Biological processes and signaling networks where the ADRB3 gene in human plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Breast Cancer Regulation by Stathmin1
- Cardiac Hypertrophy Signaling
- Cellular Effects of Sildenafil (Viagra)
- CREB Signaling in Neurons
- FAK Signaling
- G-Protein Coupled Receptor Signaling
- Gαs Signaling
- Mitochondrial Dysfunction
- Molecular Mechanisms of Cancer
- Myc Mediated Apoptosis Signaling
- Nitric Oxide Signaling in the Cardiovascular System
- Phagosome Formation
- Serotonin Receptor Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gastric cancer
- metastatic gastric cancer
- cancer
- infection
- metastasis
- neoplasia
- thyroid gland neoplasm
- Huntington disease
- major depression
- asthma
role in cell
- expression in
- induction in
- production in
- differentiation
- activation
- phosphorylation in
- quantity
- cellular infiltration by
- accumulation in
- number
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ADRB3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of multicellular organism growth
- generation of precursor metabolites and energy
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- energy reserve metabolic process
- adenylate cyclase-modulating G-protein coupled receptor signaling pathway
- positive regulation of MAPK cascade
- receptor-mediated endocytosis
- negative regulation of G-protein coupled receptor protein signaling pathway
- diet induced thermogenesis
- vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure
- eating behavior
- carbohydrate metabolic process
- brown fat cell differentiation
- response to cold
- heat generation
- adenylate cyclase-activating adrenergic receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- epinephrine binding
- protein homodimerization activity
- protein binding
- beta3-adrenergic receptor activity
- beta-adrenergic receptor activity
- norepinephrine binding
- beta-3 adrenergic receptor binding