PIAS1 Gene Summary [Human]
This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]
Details
| Type | Protein Coding |
| Official Symbol | PIAS1 |
| Official Name | protein inhibitor of activated STAT 1 [Source:HGNC Symbol;Acc:HGNC:2752] |
| Ensembl ID | ENSG00000033800 |
| Bio databases IDs | |
| Aliases | protein inhibitor of activated STAT 1, zinc finger, MIZ-type containing 3 |
| Synonyms | 2900068C24Rik, DDXBP1, GBP, GU/RH-II, protein inhibitor of activated STAT 1, protein inhibitor of activated STAT, 1, ZMIZ3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PIAS1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PINIT domain
- STAT binding domain
- SUMO ligase
- ubiquitin protein ligase binding
- transcription regulator
- SAP motif
- SUMO transferase activity
- nucleic acid binding
- transcription co-repressor
- enzyme binding
- transcription factor binding
- protein domain specific binding
- protein binding
- sequence-specific DNA binding
- acidic domain
- ring like zinc finger domain
- SAF-box
- double-stranded DNA binding
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- MIZ/SP-RING zinc finger
- serine threonine rich domain
Pathways
Biological processes and signaling networks where the PIAS1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tumorigenesis
- hemorrhoid
- cortisol-producing adrenal cortical adenoma
- adenoma formation
- breast cancer
- nephronophthisis
role in cell
- expression in
- apoptosis
- proliferation
- degradation in
- activation in
- differentiation
- binding in
- transactivation in
- accumulation in
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- glutaminergic synapse
- Cytoplasm
- cytosol
- nuclear foci
- nucleoplasm
- nuclear speckles
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PIAS1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein sumoylation
- protein-DNA complex assembly
- spermatogenesis
- visual learning
- fat cell differentiation
- response to DNA damage stimulus
- regulation of cell proliferation
- JAK-STAT cascade
- regulation of transcription from RNA polymerase II promoter
- negative regulation of transcription from RNA polymerase II promoter
- positive regulation of transcription, DNA-dependent
- negative regulation of apoptotic process
- positive regulation of smooth muscle cell differentiation
- G1/S transition of mitotic cell cycle
- positive regulation of protein sumoylation
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- PML body
- cytoplasm
- nuclear speck
- nuclear periphery
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein domain specific binding
- zinc ion binding
- transcription cofactor activity
- protein binding
- ubiquitin protein ligase binding
- transcription corepressor activity
- transcription regulatory region sequence-specific DNA binding
- SUMO ligase activity
- enzyme binding