ACOT8 Gene Summary [Human]
The protein encoded by this gene is a peroxisomal thioesterase that appears to be involved more in the oxidation of fatty acids rather than in their formation. The encoded protein can bind to the human immunodeficiency virus-1 protein Nef, and mediate Nef-induced down-regulation of CD4 in T-cells. [provided by RefSeq, Oct 2010]
Details
| Type | Protein Coding |
| Official Symbol | ACOT8 |
| Official Name | acyl-CoA thioesterase 8 [Source:HGNC Symbol;Acc:HGNC:15919] |
| Ensembl ID | ENSG00000101473 |
| Bio databases IDs | |
| Aliases | acyl-CoA thioesterase 8, choloyl-CoA hydrolase, Nef (lentivirus myristoylated factor) associated protein 1 |
| Synonyms | acyl-CoA thioesterase 8, hACTE-III, HNAACTE, hTE, NAP1, PTE-1, PTE-2, Te |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ACOT8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- palmitoyl-CoA hydrolase
- acyl-CoA thioesterase
- Thioesterase-like superfamily
- acetyl-CoA hydrolase
- acyl-CoA thioesterase II
- ADP-dependent medium-chain-acyl-CoA hydrolase
- CoA hydrolase
- hot_dog
- enzyme
- protein binding
- peroxisome targeting signal
- acyl-CoA hydrolase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- enteritis
role in cell
- proliferation
- formation
- formation in
- quantity
- expression in
- proliferation in
- fission
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- peroxisomal matrix
- cytosol
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ACOT8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acyl-CoA metabolic process
- fatty acid catabolic process
- peroxisome fission
- dicarboxylic acid catabolic process
- fatty acid beta-oxidation using acyl-CoA oxidase
- negative regulation of CD4 biosynthetic process
- alpha-linolenic acid metabolic process
- bile acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cytosol
- peroxisomal matrix
Molecular Function
What the gene product does at the molecular level
- acetyl-CoA hydrolase activity
- succinyl-CoA hydrolase activity
- protein binding
- hydroxymethylglutaryl-CoA hydrolase activity
- long-chain acyl-CoA hydrolase activity
- choloyl-CoA hydrolase activity
- medium-chain acyl-CoA hydrolase activity
- acyl-CoA hydrolase activity
- CoA hydrolase activity
- carboxylic ester hydrolase activity
- acetoacetyl-CoA hydrolase activity