CDC27 Gene Summary

The protein encoded by this gene shares strong similarity with Saccharomyces cerevisiae protein Cdc27, and the gene product of Schizosaccharomyces pombe nuc 2. This protein is a component of the anaphase-promoting complex (APC), which is composed of eight protein subunits and is highly conserved in eukaryotic cells. This complex catalyzes the formation of cyclin B-ubiquitin conjugate, which is responsible for the ubiquitin-mediated proteolysis of B-type cyclins. The protein encoded by this gene and three other members of the APC complex contain tetratricopeptide (TPR) repeats, which are important for protein-protein interactions. This protein was shown to interact with mitotic checkpoint proteins including Mad2, p55CDC and BUBR1, and it may thus be involved in controlling the timing of mitosis. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 22 and Y. [provided by RefSeq, May 2014]

Details

Type
Protein Coding
Official Symbol
CDC27
Official Name
cell division cycle 27 [Source:HGNC Symbol;Acc:HGNC:1728]
Ensembl ID
ENSG00000004897
Bio databases IDs NCBI: 996 Ensembl: ENSG00000004897
Aliases cell division cycle 27, anaphase promoting complex subunit 3
Synonyms
AI452358,ANAPC3,APC3,CDC27Hs,cell division cycle 27,D0S1430E,D17S978E,H-NUC,NUC2
Species
Human, Homo sapiens

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • TPR repeat
  • protein phosphatase binding
  • Tetratricopeptide repeats
  • protein binding
  • tetratricopeptide repeat
  • Anaphase-promoting complex, cyclosome, subunit 3

Pathways

Biological processes and signaling networks where the CDC27 gene plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • hypertension
  • Alzheimer disease
  • non-insulin-dependent diabetes mellitus
  • essential hypertension
  • major depression
  • acute coronary syndrome
  • sporadic systemic lupus erythematosus
  • erythema nodosum
  • Waldenström macroglobulinemia
  • familial systemic lupus erythematosus
regulated by
role in cell
  • expression in
  • replication in
  • morphogenesis
  • cell cycle progression
  • biogenesis by
  • degradation in
  • escape
  • biogenesis in
  • contact growth inhibition
  • biogenesis

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • Nucleus
  • spindle apparatus
  • Cytoplasm
  • centrosome
  • centriole
  • cytosol
  • nucleoplasm
  • mitotic spindle

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the CDC27 gene, providing context for its role in the cell.

biological PROCESS

Functions and activities the gene product is involved in
  • cell division
  • regulation of meiotic cell cycle
  • protein K11-linked ubiquitination
  • protein K48-linked ubiquitination
  • anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
  • mitotic metaphase/anaphase transition
  • regulation of mitotic cell cycle
  • protein ubiquitination

cellular COMPONENT

Where in the cell the gene product is active
  • nucleus
  • centrosome
  • mitotic spindle
  • cytoplasm
  • anaphase-promoting complex
  • spindle
  • cytosol
  • nucleoplasm

molecular FUNCTION

What the gene product does at the molecular level
  • protein phosphatase binding
  • protein binding

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.