VSIG1 Gene Summary [Human]
This gene encodes a member of the junctional adhesion molecule (JAM) family. The encoded protein contains multiple glycosylation sites at the N-terminal region, and multiple phosphorylation sites and glutamic acid/proline (EP) repeats at the C-terminal region. The gene is expressed in normal stomach and testis, as well as in gastric, esophageal and ovarian cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2009]
Details
| Type | Protein Coding |
| Official Symbol | VSIG1 |
| Official Name | V-set and immunoglobulin domain containing 1 [Source:HGNC Symbol;Acc:HGNC:28675] |
| Ensembl ID | ENSG00000101842 |
| Bio databases IDs | |
| Aliases | V-set and immunoglobulin domain containing 1, glycoprotein A34 |
| Synonyms | 1700062D20Rik, 4930405J24Rik, AL672306.1, dJ889N15.1, GPA34, V-set and immunoglobulin domain containing 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human VSIG1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- Immunoglobulin V-set domain
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- basolateral membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human VSIG1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell morphogenesis
- maintenance of gastrointestinal epithelium
Cellular Component
Where in the cell the gene product is active
- basolateral plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding