EEA1 Gene Summary [Human]
Enables 1-phosphatidylinositol binding activity; GTP-dependent protein binding activity; and protein homodimerization activity. Involved in endocytosis; vesicle fusion; and viral RNA genome replication. Located in cytosol and early endosome. Is extrinsic component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | EEA1 |
| Official Name | early endosome antigen 1 [Source:HGNC Symbol;Acc:HGNC:3185] |
| Ensembl ID | ENSG00000102189 |
| Bio databases IDs | |
| Aliases | early endosome antigen 1 |
| Synonyms | A430109M19RIK, B230358H09Rik, early endosome antigen 1, MST105, MSTP105, ZFYVE2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EEA1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mitotic checkpoint protein
- Crescentin protein
- FYVE zinc finger
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- GTP-dependent protein binding
- rad50
- Synaptonemal complex protein 1 (SCP-1)
- calmodulin binding domain
- Myosin tail
- helix-rich Mycoplasma protein
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
- zinc binding domain
- phosphatidylinositol binding
- FYVE domain like superfamily
- chromosome segregation protein SMC, common bacterial type
- RecF/RecN/SMC N terminal domain
- RIM-binding protein of the cytomatrix active zone
- zinc ion binding
- Protein present in Fab1, YOTB, Vac1, and EEA1
- protein homodimerization
- PHD finger superfamily
- zinc finger domain
Pathways
Biological processes and signaling networks where the EEA1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Hutchinson-Gilford progeria syndrome
- neuroticism
- infection by murine hepatitis virus
- infection by Dengue virus 2
role in cell
- replication in
- production in
- quantity
- apoptosis
- activation in
- phosphorylation in
- fusion
- outgrowth
- fusion in
- missorting in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- early endosomal fractions
- soluble fraction
- endoplasmic reticulum fraction
- endosomal fractions
- membrane fraction
- endosomal membrane fractions
- megasome
- glutaminergic synapse
- perinuclear region
- intracellular membranes
- cellular membrane
- Nucleus
- vacuole
- Plasma Membrane
- endosomes
- vesicles
- cytoplasmic aggregates
- cytosol
- microdomains
- apical membrane
- trans Golgi network
- endosomal compartment
- endosomal membrane
- neurites
- synapse
- recycling endosomes
- early endosomes
- perinuclear vesicles
- cytoplasmic vesicles
- endocytotic vesicle
- melanosomes
- sorting endosomes
- phagosomes
- detergent-soluble fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EEA1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle fusion
- early endosome to late endosome transport
- synaptic vesicle to endosome fusion
- endocytosis
Cellular Component
Where in the cell the gene product is active
- axonal spine
- early endosome membrane
- early endosome
- extracellular vesicular exosome
- serine-pyruvate aminotransferase complex
- cytosol
- recycling endosome
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- calmodulin binding
- protein homodimerization activity
- protein binding
- 1-phosphatidylinositol binding
- GTP-dependent protein binding