GPR50 Gene Summary [Human]
This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women. [provided by RefSeq, Jan 2010]
Details
| Type | Protein Coding |
| Official Symbol | GPR50 |
| Official Name | G protein-coupled receptor 50 [Source:HGNC Symbol;Acc:HGNC:4506] |
| Ensembl ID | ENSG00000102195 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 50 |
| Synonyms | G-protein-coupled receptor 50, H9, Mel1c, MRR |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GPR50 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- transmembrane domain
- 7 transmembrane receptor (rhodopsin family)
- tail domain
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the GPR50 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- nucleoplasm
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GPR50 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- G-protein coupled receptor signaling pathway
- cell-cell signaling
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- melatonin receptor activity