HTATSF1 Gene Summary [Human]
The protein encoded by this gene functions as a cofactor for the stimulation of transcriptional elongation by HIV-1 Tat, which binds to the HIV-1 promoter through Tat-TAR interaction. This protein may also serve as a dual-function factor to couple transcription and splicing and to facilitate their reciprocal activation. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Sep 2009]
Details
| Type | Protein Coding |
| Official Symbol | HTATSF1 |
| Official Name | HIV-1 Tat specific factor 1 [Source:HGNC Symbol;Acc:HGNC:5276] |
| Ensembl ID | ENSG00000102241 |
| Bio databases IDs | |
| Aliases | HIV-1 Tat specific factor 1 |
| Synonyms | 1600023H17Rik, 2600017A12RIK, 2700077B20Rik, dJ196E23.2, HIV-1 Tat specific factor 1, HIV TAT specific factor 1, RGD1563377, TAT-SF1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human HTATSF1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- transcription regulator
- RNA recognition motif
- protein binding activity, bridging
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- breast cancer
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- colorectal carcinomagenesis
- breast carcinoma
- lung adenocarcinoma
- lung adenocarcinoma formation
- rectal adenocarcinoma
regulates
role in cell
- talazoparib sensitivity
- splicing by
- cisplatin sensitivity
- rucaparib sensitivity
- camptothecin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- spliceosomes
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human HTATSF1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- double-strand break repair via homologous recombination
- chromatin organization
- nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- site of double-strand break
- spliceosomal complex
- U2-type spliceosomal complex
- U2 snRNP
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding