TOPBP1
TOPBP1 Gene Summary
This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. [provided by RefSeq, Jul 2008]
Details
| Type | Processed Transcript |
| Official Symbol | TOPBP1 |
| Official Name | DNA topoisomerase II binding protein 1 [Source:HGNC Symbol;Acc:HGNC:17008] |
| Ensembl ID | ENSG00000163781 |
| Bio databases IDs | |
| Aliases | DNA topoisomerase II binding protein 1 |
| Synonyms | 1110031N14RIK,2810429C13Rik,D430026L04Rik,DNA topoisomerase II binding protein 1,Dpb11,mKIAA0259,RGD1562949,TOP2BP1,TOPO2 BP,TOPOISOMERASE2 binding,topoisomerase (DNA) II binding protein 1 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase activator
- BRCT
- twin BRCT domain
- BRCA1-binding domain
- BRCA1 C Terminus (BRCT) domain
- BRCT domain, a BRCA1 C-terminus domain
- nuclear localization sequence
- protein binding activity, bridging
- protein binding
- identical protein binding
- breast cancer carboxy-terminal domain
- BRCT-like domain
Pathways
Biological processes and signaling networks where the TOPBP1 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- TOP2B
- DDB1
- CIP2A
- BLM
- TTC31
- PSME3
- TP53
- ABL1
- RPAP2
- ATRIP
disease
- rheumatoid arthritis
- breast cancer
- neoplasia
- epithelial cancer
- liver cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- hepatocellular carcinoma
- mammary neoplasm
- breast carcinoma
regulated by
- 26S proteasome
- RAD9A
- ATM
- MLH1
- silmitasertib
- RB1
- PML
- tretinoin
- TOPBP1
- E2F1
regulates
- TP53
- BAX
- CDKN2B
- IGFBP3
- BLM
- RAD51
- COQ8A
- CDK2
- ABL1
- CHEK1
role in cell
- growth
- survival
- expression in
- synthesis in
- cell death
- apoptosis
- phosphorylation in
- proliferation
- formation in
- damage in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- actin cytoskeleton
- Plasma Membrane
- nuclear foci
- chromosome
- nucleoplasm
- nuclear bodies
- PML nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the TOPBP1 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- DNA-dependent DNA replication initiation
- DNA repair
- mitotic cell cycle G2/M transition DNA damage checkpoint
- double-strand break repair via homologous recombination
- DNA metabolic process
- response to DNA damage stimulus
- chromatin organization
- DNA damage checkpoint
- DNA replication checkpoint
- chromosome organization
- reciprocal DNA recombination
- mitotic cell cycle DNA replication checkpoint
- response to ionizing radiation
CELLULAR COMPONENT
Where in the cell the gene product is active
- nuclear body
- site of double-strand break
- PML body
- spindle pole
- chromosome
- plasma membrane
- nucleoplasm
- male germ cell nucleus
- condensed nuclear chromosome
- nucleus
- centrosome
- cytoplasm
- actin cytoskeleton
- BRCA1-B complex
MOLECULAR FUNCTION
What the gene product does at the molecular level
- DNA binding
- identical protein binding
- protein serine/threonine kinase activator activity
- protein binding