PIN4 Gene Summary [Human]
This gene encodes a member of the parvulin subfamily of the peptidyl-prolyl cis/trans isomerase protein family. The encoded protein catalyzes the isomerization of peptidylprolyl bonds, and may play a role in the cell cycle, chromatin remodeling, and/or ribosome biogenesis. The encoded protein may play an additional role in the mitochondria. [provided by RefSeq, Dec 2009]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | PIN4 |
| Official Name | peptidylprolyl cis/trans isomerase, NIMA-interacting 4 [Source:HGNC Symbol;Acc:HGNC:8992] |
| Ensembl ID | ENSG00000102309 |
| Bio databases IDs | |
| Aliases | peptidylprolyl cis/trans isomerase, NIMA-interacting 4, parvulin |
| Synonyms | 2410002I22Rik, EPVH, hEPVH, hPar14, hPar17, PAR14, Parvulin 14, peptidylprolyl cis/trans isomerase, NIMA-interacting 4, peptidyl-prolyl cis/trans isomerase, NIMA-interacting, 4 (parvulin), PPIase Pin4, Rotamase Pin4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PIN4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- double-stranded DNA binding
- bent DNA binding
- enzyme
- PPIC-type PPIASE domain
- glycine lysine rich domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- pre-ribosome
- spindle apparatus
- Cytoplasm
- mitochondrial matrix
- chromosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PIN4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial matrix
- spindle
- chromosome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- peptidyl-prolyl cis-trans isomerase activity
- RNA binding
- protein binding