Pin4 Gene Summary [Mouse]
Predicted to enable bent DNA binding activity and double-stranded DNA binding activity. Predicted to be involved in rRNA processing. Predicted to be located in several cellular components, including mitochondrial matrix; nuclear lumen; and spindle. Predicted to be part of preribosome. Predicted to be active in nucleus. Is expressed in 2-cell stage embryo and 4-cell stage embryo. Orthologous to human PIN4 (peptidylprolyl cis/trans isomerase, NIMA-interacting 4). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pin4 |
| Official Name | protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) [Source:MGI Symbol;Acc:MGI:1916963] |
| Ensembl ID | ENSMUSG00000079480 |
| Bio databases IDs | |
| Aliases | protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin) |
| Synonyms | 2410002I22Rik, EPVH, hEPVH, hPar14, hPar17, PAR14, Parvulin 14, peptidylprolyl cis/trans isomerase, NIMA-interacting 4, peptidyl-prolyl cis/trans isomerase, NIMA-interacting, 4 (parvulin), PPIase Pin4, Rotamase Pin4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pin4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- double-stranded DNA binding
- bent DNA binding
- enzyme
- PPIC-type PPIASE domain
- glycine lysine rich domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- impaired glucose tolerance
- hyperglycemia
regulates
- AKT
- oxygen
- IRS1
- G6PC1
- PEPCK
- PI3K p85
role in cell
- phosphorylation in
- binding in
- number
- processing in
- tyrosine phosphorylation in
- consumption in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- pre-ribosome
- spindle apparatus
- Cytoplasm
- mitochondrial matrix
- chromosome
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pin4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- rRNA processing
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial matrix
- spindle
- chromosome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- peptidyl-prolyl cis-trans isomerase activity
- RNA binding
- protein binding