DRP2 Gene Summary [Human]
Members of the dystrophin family of proteins perform a critical role in the maintenance of membrane-associated complexes at points of intercellular contact in vertebrate cells. The protein encoded by this gene is predicted to resemble certain short C-terminal isoforms of dystrophin and dystrophin-related protein 1 (DRP1 or utrophin). DRP2 is expressed principally in the brain and spinal cord. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
Details
| Type | Protein Coding |
| Official Symbol | DRP2 |
| Official Name | dystrophin related protein 2 [Source:HGNC Symbol;Acc:HGNC:3032] |
| Ensembl ID | ENSG00000102385 |
| Bio databases IDs | |
| Aliases | dystrophin related protein 2 |
| Synonyms | dystrophin related protein 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DRP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- EF-Hand
- SPEC
- ZZ
- Spectrin repeats
- Domain with 2 conserved Trp (W) residues
- EF hand
- WW
- EF-hand-like motif found in the dystrophin/dystrobrevin/dystrotelin family
- Spectrin repeat
- coiled-coil domain
- protein binding
- WW domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- glutaminergic synapse
- cytosol
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DRP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- central nervous system development
- synapse organization
Cellular Component
Where in the cell the gene product is active
- dendrite
- postsynaptic density
- perikaryon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- zinc ion binding