OLFM4 Gene Summary [Human]
This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011]
Details
| Type | Protein Coding |
| Official Symbol | OLFM4 |
| Official Name | olfactomedin 4 [Source:HGNC Symbol;Acc:HGNC:17190] |
| Ensembl ID | ENSG00000102837 |
| Bio databases IDs | |
| Aliases | olfactomedin 4 |
| Synonyms | bA209J19.1, DIFFERENTIALLY EXPRESSED IN haematoPOIETIC LINEAGES, DIFFERENTIALLY EXPRESSED IN HEMATOPOIETIC LINEAGES, GC1, Gm296, Gm913, GW112, hGC-1, hOLfD, olfactomedin 4, OlfD, OLM4, pDP4, pPD4, UNQ362 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human OLFM4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Olfactomedin-like domain
- cadherin binding
- protein binding
- structural molecule
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- tuberculosis
- epithelial cancer
- pervasive developmental disorder
- major depression
- insomnia
- sporadic amyotrophic lateral sclerosis
- dextran sodium sulfate-induced colitis
- ulcerative colitis
- idiopathic inflammatory myopathy
- colorectal neoplasia
role in cell
- expression in
- apoptosis
- phosphorylation in
- activation in
- quantity
- colonization by
- consumption in
- cellular infiltration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- secretory granule lumen
- perinuclear region
- organelle lumens
- Plasma Membrane
- cytoplasmic bridges
- cytosol
- nucleoplasm
- specific granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human OLFM4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- cell adhesion
- positive regulation of substrate adhesion-dependent cell spreading
Cellular Component
Where in the cell the gene product is active
- specific granule lumen
- secretory granule
- extracellular region
- plasma membrane
- nucleoplasm
- extracellular space
- intercellular bridge
- perinuclear region of cytoplasm
- extracellular vesicular exosome
- specific granule
- azurophil granule
- mitochondrion
- cytosol
- macromolecular complex
Molecular Function
What the gene product does at the molecular level
- protein binding
- cadherin binding
- structural molecule activity