PTGER2 Gene Summary [Human]
This gene encodes a receptor for prostaglandin E2, a metabolite of arachidonic acid which has different biologic activities in a wide range of tissues. Mutations in this gene are associated with aspirin-induced susceptibility to asthma. [provided by RefSeq, Oct 2009]
Details
| Type | Protein Coding |
| Official Symbol | PTGER2 |
| Official Name | prostaglandin E receptor 2 [Source:HGNC Symbol;Acc:HGNC:9594] |
| Ensembl ID | ENSG00000125384 |
| Bio databases IDs | |
| Aliases | prostaglandin E receptor 2 |
| Synonyms | EP2, LOC100360765, PGE2 receptor, prostaglandin E receptor 2, prostaglandin E receptor 2 (subtype EP2), Ptger-ep2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PTGER2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- intracellular loop
- prostaglandin E receptor
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the PTGER2 gene in human plays a role, providing insight into its function and relevance in health or disease.
- Breast Cancer Regulation by Stathmin1
- cAMP-mediated signaling
- Cellular Effects of Sildenafil (Viagra)
- Colorectal Cancer Metastasis Signaling
- CREB Signaling in Neurons
- Eicosanoid Signaling
- Endothelin-1 Signaling
- FAK Signaling
- G-Protein Coupled Receptor Signaling
- Gαs Signaling
- Phagosome Formation
- Renin-Angiotensin Signaling
- Th17 Activation Pathway
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- hepatic steatosis
- hyperplasia
- weight loss
- bleeding
- pain
- rheumatoid arthritis
- osteoarthritis
- mammary neoplasm
- gestational trophoblastic disease
role in cell
- expression in
- apoptosis
- production in
- autophagy in
- invasion by
- proliferation
- function
- activation
- upregulation in
- quantity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cell surface
- cellular membrane
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PTGER2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- G-protein coupled receptor signaling pathway
- response to progesterone stimulus
- response to lipopolysaccharide
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- cellular response to prostaglandin E stimulus
- regulation of cell proliferation
- response to nematode
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- prostaglandin E receptor activity