CORO1A Gene Summary [Human]
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. Alternative splicing results in multiple transcript variants. A related pseudogene has been defined on chromosome 16. [provided by RefSeq, Sep 2010]
Details
| Type | Protein Coding |
| Official Symbol | CORO1A |
| Official Name | coronin 1A [Source:HGNC Symbol;Acc:HGNC:2252] |
| Ensembl ID | ENSG00000102879 |
| Bio databases IDs | |
| Aliases | coronin 1A, Clabp TACO |
| Synonyms | Actin binding protein 1a, CLABP, CLIPINA, Coronin 1, coronin 1A, coronin, actin binding protein 1A, HCORO1, IMD8, Lmb3, p57, TACO |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CORO1A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WD domain, G-beta repeat
- leucine zipper domain
- coiled-coil domain
- WD40
- protein binding
- identical protein binding
- Domain of unknown function (DUF1899)
- trimerization motif
- actin filament binding
- myosin binding
- phosphoinositide 3-kinase binding
- WD40 repeats
- Type of WD40 repeat
- cytoskeletal protein binding
- actin monomer binding
- actin binding
- protein homodimerization
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- severe combined immunodeficiency
- chronic sinusitis
- experimental autoimmune encephalomyelitis
- Parkinson disease
- sinus-node dysfunction
- hypersensitivity reaction type I
- diabetic nephropathy
- laser induced choroidal neovascularization
- renal clear cell adenocarcinoma
- renal clear cell cancer
role in cell
- proliferation
- cell death
- activation in
- growth
- apoptosis
- signaling in
- phosphorylation in
- number
- adhesion
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- membrane fraction
- glutaminergic synapse
- cortical actin cytoskeleton
- cytoskeleton
- cell periphery
- actin cytoskeleton
- cell cortex
- Nucleus
- Plasma Membrane
- microtubules
- actin filaments
- intercellular junctions
- immunological synapses
- cytosol
- stereocilia
- plasma membrane projections
- synaptic vesicles
- synapse
- early endosomes
- cell membrane leading edge
- axons
- phagosomes
- plasma
- lamellipodia
- phagocytic cups
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CORO1A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- positive chemotaxis
- actin filament organization
- natural killer cell degranulation
- immunological synapse formation
- T cell homeostasis
- negative regulation of neuron apoptotic process
- negative regulation of actin nucleation
- negative regulation of vesicle fusion
- phagolysosome assembly
- calcium ion transport
- cellular response to interleukin-4
- cell migration
- neuron apoptotic process
- epithelial cell migration
- positive regulation of T cell proliferation
- regulation of actin filament polymerization
- regulation of release of sequestered calcium ion into cytosol
- positive regulation of T cell migration
- regulation of actin cytoskeleton organization
- homeostasis of number of cells within a tissue
- vesicle fusion
- innate immune response
- T cell proliferation
- thymocyte migration
- phagocytosis
- uropod organization
- leukocyte chemotaxis
- cell-substrate adhesion
- actin cytoskeleton organization
Cellular Component
Where in the cell the gene product is active
- phagocytic vesicle
- actin filament
- phagocytic cup
- plasma membrane
- immunological synapse
- nucleus
- early endosome
- extracellular vesicular exosome
- cell-cell junction
- cytoplasm
- membrane
- phagocytic vesicle membrane
- cytosol
- macromolecular complex
- axon
- cortical actin cytoskeleton
- lamellipodium
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- phosphatidylinositol 3-kinase binding
- protein homodimerization activity
- RNA binding
- protein binding
- actin binding
- myosin heavy chain binding
- cytoskeletal protein binding
- actin monomer binding