DHODH Gene Summary [Human]
The protein encoded by this gene catalyzes the fourth enzymatic step, the ubiquinone-mediated oxidation of dihydroorotate to orotate, in de novo pyrimidine biosynthesis. This protein is a mitochondrial protein located on the outer surface of the inner mitochondrial membrane. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | DHODH |
| Official Name | dihydroorotate dehydrogenase (quinone) [Source:HGNC Symbol;Acc:HGNC:2867] |
| Ensembl ID | ENSG00000102967 |
| Bio databases IDs | |
| Aliases | dihydroorotate dehydrogenase (quinone) |
| Synonyms | 2810417D19Rik, DHOdehase, dihydroorotate dehydrogenase, dihydroorotate dehydrogenase (quinone), POADS, URA1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DHODH often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- dihydroorotate oxidase
- quinone binding
- dihydroorotase
- TIM-like beta/alpha barrel domains
- FMN binding
- ubiquinone binding
- CH-CH group:quinone oxidoreductase
- dihydroorotate dehydrogenase, subfamily 2
- dihydroorotate dehydrogenase (subfamily 1) family protein
- enzyme
- protein binding
- dihydroorotate dehydrogenase
Pathways
Biological processes and signaling networks where the DHODH gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- COVID-19
- psoriatic arthritis
- arthritis
- multiple sclerosis
- lupus nephritis
- relapsing-remitting multiple sclerosis
- juvenile rheumatoid arthritis
- Miller syndrome
- hepatocellular carcinoma
role in cell
- phosphorylation in
- expression in
- cell viability
- apoptosis
- activation in
- inactivation in
- ferroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Mitochondria
- cytosol
- mitochondrial inner membrane
- nucleoplasm
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DHODH gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- 'de novo' pyrimidine base biosynthetic process
- pyrimidine ribonucleotide biosynthetic process
- 'de novo' UMP biosynthetic process
- UDP biosynthetic process
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- cytosol
- mitochondrial inner membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- dihydroorotase activity
- dihydroorotate dehydrogenase activity