FUT8 Gene Summary [Human]
This gene encodes an enzyme belonging to the family of fucosyltransferases. The product of this gene catalyzes the transfer of fucose from GDP-fucose to N-linked type complex glycopeptides. This enzyme is distinct from other fucosyltransferases which catalyze alpha1-2, alpha1-3, and alpha1-4 fucose addition. The expression of this gene may contribute to the malignancy of cancer cells and to their invasive and metastatic capabilities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]
Details
| Type | Protein Coding |
| Official Symbol | FUT8 |
| Official Name | fucosyltransferase 8 [Source:HGNC Symbol;Acc:HGNC:4019] |
| Ensembl ID | ENSG00000033170 |
| Bio databases IDs | |
| Aliases | fucosyltransferase 8, alpha (1,6) fucosyltransferase |
| Synonyms | alpha-1,6-fucosyltransferase, CDGF, CDGF1, fucosyltransferase 8, LOC105370537, N-ACETYL-beta-D-GLUCOSAMINIDE alpha1,6-FUCOSYLTRANSFERASE, N-ACETYL-β-D-GLUCOSAMINIDE alpha1,6-FUCOSYLTRANSFERASE, α-1,6-fucosyltransferase |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FUT8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GDP-fucose protein O-fucosyltransferase and related proteins
- donor substrate-binding domain
- Alpha-(1,6)-fucosyltransferase N- and catalytic domains
- flexible loop regulatory domain
- alpha(1,6)-fucosyltransferase
- glycoprotein 6-alpha-L-fucosyltransferase
- enzyme
- protein binding
- glycosyltransferase
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- fibrosis
- epithelial cancer
- lung squamous cell carcinoma
- squamous cell lung cancer
- metastasis
- lung adenocarcinoma
- lung adenocarcinoma formation
- soft tissue sarcoma cancer
- congenital disorder of glycosylation with defective fucosylation 1
role in cell
- phosphorylation in
- activation in
- migration
- formation
- formation in
- invasion by
- expression in
- activation
- apoptosis
- production in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- Golgi membrane
- trans Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FUT8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- N-glycan processing
- receptor metabolic process
- transforming growth factor beta receptor signaling pathway
- protein N-linked glycosylation
- N-glycan fucosylation
- oligosaccharide biosynthetic process
- GDP-L-fucose metabolic process
- respiratory gaseous exchange
- L-fucose catabolic process
- regulation of cellular response to oxidative stress
- viral protein processing
- integrin-mediated signaling pathway
- in utero embryonic development
- regulation of gene expression
- protein N-linked glycosylation via asparagine
- fibroblast migration
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- Golgi cisterna membrane
- membrane
- Golgi membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- protein binding
- SH3 domain binding
- alpha-(1->6)-fucosyltransferase activity
- glycoprotein 6-alpha-L-fucosyltransferase activity