OIP5 Gene Summary [Human]
The protein encoded by this gene localizes to centromeres, where it is essential for recruitment of CENP-A through the mediator Holliday junction recognition protein. Expression of this gene is upregulated in several cancers, making it a putative therapeutic target. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]
Details
| Type | Protein Coding |
| Official Symbol | OIP5 |
| Official Name | Opa interacting protein 5 [Source:HGNC Symbol;Acc:HGNC:20300] |
| Ensembl ID | ENSG00000104147 |
| Bio databases IDs | |
| Aliases | Opa interacting protein 5, MIS18 kinetochore protein homolog B (S. pombe), cancer/testis antigen 86 |
| Synonyms | 5730547N13Rik, CT86, hMIS18beta, LINT-25, MIS18B, MIS18beta, Ms18b, Opa interacting protein 5, RGD1564263 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human OIP5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RLR_C_like
- protein binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ovarian cancer
- COVID-19
- Parkinson disease
- small cell lung cancer
- chromosomal instability
role in cell
- expression in
- proliferation
- apoptosis
- migration
- quantity
- G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- intracellular membrane-bounded organelle
- chromosome
- nucleoplasm
- nuclear speckles
- Cajal bodies
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human OIP5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- cell communication
- chromosome segregation
- CenH3-containing nucleosome assembly at centromere
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear speck
- intracellular membrane-bounded organelle
- Cajal body
- chromocenter
- chromosome, centromeric region
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- metal ion binding