CCNA2 Gene Summary [Human]
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members function as regulators of the cell cycle. This protein binds and activates cyclin-dependent kinase 2 and thus promotes transition through G1/S and G2/M. [provided by RefSeq, Aug 2016]
Details
| Type | Protein Coding |
| Official Symbol | CCNA2 |
| Official Name | cyclin A2 [Source:HGNC Symbol;Acc:HGNC:1578] |
| Ensembl ID | ENSG00000145386 |
| Bio databases IDs | |
| Aliases | cyclin A2 |
| Synonyms | CCN1, CCNA, Cyca, CycA2, Cyclin a2, p60 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CCNA2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cyclin-A N-terminal APC/C binding region
- cyclin box
- destruction box
- protein kinase binding
- Cyclin box fold superfamily
- protein domain specific binding
- Cyclin, N-terminal domain
- protein binding
- domain present in cyclins, TFIIB and Retinoblastoma
- cyclin-dependent protein kinase regulator
Pathways
Biological processes and signaling networks where the CCNA2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- liver neoplasia
- epithelial cancer
- osteosarcomagenesis
- oral squamous cell carcinoma
- hepatocellular carcinoma
- HER2 negative hormone receptor negative breast cancer
- endometriosis
- lung adenocarcinoma
role in cell
- expression in
- apoptosis
- proliferation
- inhibition in
- quantity
- ploidy
- cell viability
- growth
- phosphorylation in
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- Cytoplasm
- cytosol
- nucleoplasm
- pronucleus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CCNA2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cochlea development
- transcription, DNA-dependent
- cellular response to platelet-derived growth factor stimulus
- regulation of DNA replication
- Ras protein signal transduction
- post-translational protein modification
- regulation of cyclin-dependent protein kinase activity
- cell division
- cellular response to luteinizing hormone stimulus
- cellular response to estradiol stimulus
- G2/M transition of mitotic cell cycle
- positive regulation of transcription, DNA-dependent
- positive regulation of fibroblast proliferation
- cellular response to leptin stimulus
- G1/S transition of mitotic cell cycle
- cellular response to nitric oxide
- cellular response to cocaine
- response to glucagon stimulus
- cellular response to hypoxia
- organ regeneration
- positive regulation of DNA biosynthetic process
Cellular Component
Where in the cell the gene product is active
- cyclin A2-CDK1 complex
- nucleus
- male pronucleus
- cyclin A2-CDK2 complex
- centrosome
- cytoplasm
- cyclin-dependent protein kinase holoenzyme complex
- cytosol
- female pronucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein domain specific binding
- protein binding
- cyclin-dependent protein kinase regulator activity