GML Gene Summary [Human]

Predicted to be involved in DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; apoptotic process; and negative regulation of cell population proliferation. Predicted to be extrinsic component of membrane. [provided by Alliance of Genome Resources, Apr 2022]

Details

Type
Protein Coding
Official Symbol
GML
Official Name
glycosylphosphatidylinositol anchored molecule like [Source:HGNC Symbol;Acc:HGNC:4375]
Ensembl ID
ENSG00000104499
Bio databases IDs NCBI: 2765 Ensembl: ENSG00000104499
Aliases glycosylphosphatidylinositol anchored molecule like
Synonyms EG625599, glycosylphosphatidylinositol anchored molecule like, HemT, LY6DL
Species
Human, Homo sapiens
OrthologiesMouseRat

Protein Domains

A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GML often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
  • TFP

Pathways

Biological processes and signaling networks where the GML gene in human plays a role, providing insight into its function and relevance in health or disease.

Top Findings

The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
  • hypertension
  • resistant hypertension
  • osteoarthritis
  • primary hyperaldosteronism
  • infection by HIV-1
regulated by
role in cell
  • proliferation
  • cell death
  • apoptosis
  • sensitization

Subcellular Expression

Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
  • cellular membrane
  • Plasma Membrane

Gene Ontology Annotations

Describes the biological processes, cellular components, and molecular functions associated with the human GML gene, providing context for its role in the cell.

Biological Process

Functions and activities the gene product is involved in
  • DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
  • negative regulation of cell proliferation
  • apoptotic process

Cellular Component

Where in the cell the gene product is active
  • extrinsic to membrane
  • plasma membrane

Gene-Specific Assays for Results You Can Trust

Streamline your workflow with assays designed for this gene. Our targeted dPCR and qPCR assays help you generate meaningful data – efficiently and accurately.