TNFAIP2 Gene Summary [Human]
This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. The expression of this gene was shown to be induced by retinoic acid in a cell line expressing a oncogenic version of the retinoic acid receptor alpha fusion protein, which suggested that this gene may be a retinoic acid target gene in acute promyelocytic leukemia. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TNFAIP2 |
| Official Name | TNF alpha induced protein 2 [Source:HGNC Symbol;Acc:HGNC:11895] |
| Ensembl ID | ENSG00000185215 |
| Bio databases IDs | |
| Aliases | TNF alpha induced protein 2, exocyst complex component 3-like 3 |
| Synonyms | ABC transporter, B94, EXOC3L3, LOC102723726, LOC299339, M-sec, TNAP2, TNF alpha-INDUCED protein 2, tnfb94, Tnfip2, TNF α-INDUCED protein 2, Tnp2, tumor necrosis factor, alpha-induced protein 2, tumor necrosis factor, α-induced protein 2, tumour necrosis factor, alpha-induced protein 2, tumour necrosis factor, α-induced protein 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TNFAIP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Exocyst complex component Sec6
- protein binding
Pathways
Biological processes and signaling networks where the TNFAIP2 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- Marfan syndrome
- glomerulosclerosis
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- uterine serous papillary cancer
- albuminuria
role in cell
- apoptosis
- expression in
- differentiation
- formation
- activation in
- abnormal morphology
- effacement
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TNFAIP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- angiogenesis
- cell differentiation
- exocytosis
- exocyst localization
Cellular Component
Where in the cell the gene product is active
- extracellular space
- exocyst
Molecular Function
What the gene product does at the molecular level
- protein binding
- SNARE binding