DCTN6 Gene Summary [Human]
The protein encoded by this gene contains an RGD (Arg-Gly-Asp) motif in the N-terminal region, which confers adhesive properties to macromolecular proteins like fibronectin. It shares a high degree of sequence similarity with the mouse homolog, which has been suggested to play a role in mitochondrial biogenesis. The exact biological function of this gene is not known. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | DCTN6 |
| Official Name | dynactin subunit 6 [Source:HGNC Symbol;Acc:HGNC:16964] |
| Ensembl ID | ENSG00000104671 |
| Bio databases IDs | |
| Aliases | dynactin subunit 6 |
| Synonyms | Dctn6 predicted, dynactin 6, dynactin subunit 6, Dynactin subunit p27, p27, WS-3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DCTN6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- LbetaH
- enzyme
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- postmenopausal osteoporosis
regulates
- motor
- dynein intermediate chain
- dynein heavy chain
- LIC
- dynein light chain
role in cell
- binding in
- translocation
- binding
- organization
- translocation in
- motor function in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- centrosome
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DCTN6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- mitotic spindle organization
Cellular Component
Where in the cell the gene product is active
- centrosome
- dynactin complex
- cytosol
- kinetochore
Molecular Function
What the gene product does at the molecular level
- dynein complex binding