FCGRT Gene Summary [Human]
This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Details
| Type | Retained Intron |
| Official Symbol | FCGRT |
| Official Name | Fc fragment of IgG receptor and transporter [Source:HGNC Symbol;Acc:HGNC:3621] |
| Ensembl ID | ENSG00000104870 |
| Bio databases IDs | |
| Aliases | Fc fragment of IgG receptor and transporter, Fc gamma receptor and transporter, heavy chain of the major histocompatibility complex class I-like Fc receptor, transmembrane alpha chain of the neonatal receptor, neonatal Fc receptor, FCRN alpha-chain |
| Synonyms | alpha-chain, Fc fragment of IgG receptor and transporter, Fc gamma receptor and transporter, FcgammaRn, Fc Receptor Igg Alpha Chain Transporter, Fc Receptor Igg α Chain Transporter, Fc receptor subunit p51, FCRN, Fc γ receptor and transporter, α-chain |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FCGRT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Immunoglobulin C1-set domain
- Class I Histocompatibility antigen, domains alpha 1 and 2
- IgG binding
- N-linked glycosylation site
- immunoglobulin domain
- IgG receptor
- protein binding
- transmembrane receptor
- beta-2-microglobulin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- generalized myasthenia gravis
- primary immune thrombocytopenia
- myasthenia gravis
- chronic inflammatory demyelinating polyradiculoneuropathy
- non-insulin-dependent diabetes mellitus
- edema
- pemphigus foliaceus
- Graves ophthalmopathy
- pemphigus vulgaris
- rheumatoid arthritis
role in cell
- binding
- damage in
- damage
- recycling in
- transcytosis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- cell surface
- intracellular space
- apical compartment
- basal compartment
- perinuclear region
- membrane surface
- cellular membrane
- endosomes
- vesicles
- lysosome
- Golgi Apparatus
- Endoplasmic Reticulum
- apical membrane
- basolateral membrane
- early endosomes
- endocytotic vesicle
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FCGRT gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor
Cellular Component
Where in the cell the gene product is active
- extracellular space
- external side of plasma membrane
- endosome membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- peptide antigen binding
- beta-2-microglobulin binding
- IgG binding