GTF2E1 Gene Summary [Human]
Enables RNA polymerase II general transcription initiation factor activity. Involved in transcription by RNA polymerase II. Located in cytosol and nucleoplasm. Part of transcription factor TFIID complex and transcription preinitiation complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | GTF2E1 |
| Official Name | general transcription factor IIE subunit 1 [Source:HGNC Symbol;Acc:HGNC:4650] |
| Ensembl ID | ENSG00000153767 |
| Bio databases IDs | |
| Aliases | general transcription factor IIE subunit 1, TFIIE alpha subunit |
| Synonyms | 2610024P03Rik, FE, general transcription factor II E, polypeptide 1 (alpha subunit), general transcription factor II E, polypeptide 1 (α subunit), general transcription factor IIE subunit 1, p56, P56E, TF2E1, TFIIE-A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GTF2E1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- TFIIB zinc-binding
- HTH_ARSR
- Transcription initiation factor IIE
- protein binding
- general RNA polymerase II transcription factor
Pathways
Biological processes and signaling networks where the GTF2E1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GTF2E1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- transcription from RNA polymerase II promoter
- transcription initiation from RNA polymerase II promoter
- transcriptional open complex formation at RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- transcription factor TFIID complex
- cytosol
- transcription factor TFIIE complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- general RNA polymerase II transcription factor activity