CKM Gene Summary [Human]
The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CKM |
| Official Name | creatine kinase, M-type [Source:HGNC Symbol;Acc:HGNC:1994] |
| Ensembl ID | ENSG00000104879 |
| Bio databases IDs | |
| Aliases | creatine kinase, M-type |
| Synonyms | CK, CKMM, CPK-M, Creatine kinase m chain, creatine kinase, M-type, creatine kinase, muscle, Creatinine kinase, Creatinine phosphokinase MM, M-CK, MUSCLE CREATINE KINASE, Phosphocreatine kinase mb |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CKM often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Phosphagen (guanidino) kinases
- creatine kinase
- ATP:guanido phosphotransferase, N-terminal domain
- protein binding
- ATP:guanido phosphotransferase, C-terminal catalytic domain
Pathways
Biological processes and signaling networks where the CKM gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- papillomatosis
- Alzheimer disease
- squamous-cell carcinoma
- squamous cell cancer
- breast cancer
- Crohn disease
- acidosis
- severe acute respiratory syndrome
- brain cancer
role in cell
- development
- morphology
- development in
- aggregation
- depolymerization in
- respiration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- cellular membrane
- Mitochondria
- myofilaments
- cytosol
- lateral plasma membrane
- anchoring junction
- cell-cell adherens junctions
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CKM gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphocreatine biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- creatine kinase activity