Ckm Gene Summary [Mouse]
Enables creatine kinase activity. Acts upstream of or within phosphocreatine biosynthetic process. Located in extracellular space. Is expressed in several structures, including alimentary system; central nervous system; heart; musculature; and sensory organ. Orthologous to human CKM (creatine kinase, M-type). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Ckm |
| Official Name | creatine kinase, muscle [Source:MGI Symbol;Acc:MGI:88413] |
| Ensembl ID | ENSMUSG00000030399 |
| Bio databases IDs | |
| Aliases | creatine kinase, muscle |
| Synonyms | CK, CKMM, CPK-M, Creatine kinase m chain, creatine kinase, M-type, creatine kinase, muscle, Creatinine kinase, Creatinine phosphokinase MM, M-CK, MUSCLE CREATINE KINASE, Phosphocreatine kinase mb |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ckm often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- kinase
- Phosphagen (guanidino) kinases
- creatine kinase
- ATP:guanido phosphotransferase, N-terminal domain
- protein binding
- ATP:guanido phosphotransferase, C-terminal catalytic domain
Pathways
Biological processes and signaling networks where the Ckm gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- papillomatosis
- Alzheimer disease
- squamous-cell carcinoma
- squamous cell cancer
- breast cancer
- Crohn disease
- acidosis
- severe acute respiratory syndrome
- brain cancer
role in cell
- development
- morphology
- development in
- aggregation
- depolymerization in
- respiration in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Extracellular Space
- cellular membrane
- Mitochondria
- myofilaments
- cytosol
- lateral plasma membrane
- anchoring junction
- cell-cell adherens junctions
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ckm gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- phosphocreatine biosynthetic process
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein binding
- creatine kinase activity