PSMD4 Gene Summary [Human]
The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. Pseudogenes have been identified on chromosomes 10 and 21. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PSMD4 |
| Official Name | proteasome 26S subunit, non-ATPase 4 [Source:HGNC Symbol;Acc:HGNC:9561] |
| Ensembl ID | ENSG00000159352 |
| Bio databases IDs | |
| Aliases | proteasome 26S subunit, non-ATPase 4, proteasome 26S subunit ubiquitin receptor, non-ATPase 4 |
| Synonyms | AF, AF-1, angiocidin, ASF, MCB1, Proteasome 26s subunit non-atpase 4, proteasome 26S subunit ubiquitin receptor, non-ATPase 4, proteasome (prosome, macropain) 26S subunit, non-ATPase, 4, pUB-R5, Rpn10, S5A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PSMD4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PUbS domain
- von Willebrand factor (vWF) type A domain
- ubiquitin binding domain
- vWFA
- KEKE domain
- von Willebrand factor type A domain
- protein binding
- identical protein binding
Pathways
Biological processes and signaling networks where the PSMD4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- growth failure
- sickle cell anemia
- productive infection by HIV-1
role in cell
- activation in
- expression in
- phosphorylation in
- proliferation
- binding in
- degradation in
- apoptosis
- phagocytosis by
- adhesion
- stabilization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- basal bodies
- cytosol
- nucleoplasm
- clastosomes
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PSMD4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- proteasome regulatory particle, base subcomplex
- cytosol
- proteasome accessory complex
- proteasome complex
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- RNA binding
- polyubiquitin binding
- binding, bridging