EID2 Gene Summary [Human]
Enables SMAD binding activity. Involved in several processes, including negative regulation of transcription, DNA-templated; negative regulation of transforming growth factor beta receptor signaling pathway; and transmembrane receptor protein serine/threonine kinase signaling pathway. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | EID2 |
| Official Name | EP300 interacting inhibitor of differentiation 2 [Source:HGNC Symbol;Acc:HGNC:28292] |
| Ensembl ID | ENSG00000176396 |
| Bio databases IDs | |
| Aliases | EP300 interacting inhibitor of differentiation 2 |
| Synonyms | CRI2, EP300 interacting inhibitor of differentiation 2, LOC687359 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human EID2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SMAD binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human EID2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- muscle organ development
- transforming growth factor beta receptor complex assembly
- negative regulation of transcription, DNA-dependent
- negative regulation of SMAD protein import into nucleus
- cell differentiation
- negative regulation of transforming growth factor beta receptor signaling pathway
- regulation of cell proliferation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- SMAD binding
- transcription corepressor activity